Research. Insights. Real talk on genomics.
Science-first content from the researchers building the tools.
How to Sequence Sex Chromosomes Accurately
Sex chromosomes are among the most difficult regions of any genome to sequence accurately. Hemizygosity, repetitive elements, palindromic regions, and structural variants make short-read methods unreliable across most of the chromosome length. Long-read low-pass sequencing resolves each of these failure modes — delivering comprehensive variant data across the full sex chromosome at population scale.
Why Can't Short-Read Sequencing Resolve Polyploid Genomes?
Short-read sequencing cannot distinguish between the duplicated chromosomes that define polyploid genomes. Here is what that failure costs — and why long-read low-pass sequencing resolves it.
Long-Read vs. Short-Read Sequencing: Which Should You Use?
Long-read and short-read sequencing are not competing technologies for the same job. Here is how to choose the right method for your research question.
What Is Long-Read Low-Pass Sequencing?
For years, researchers had to choose between sequencing quality and study scale. LRLP ends that compromise. Here is what it is and how it works.
How to Transition from SNP Arrays to Sequencing in Your Breeding Program
SNP arrays have served plant breeding well. But fixed marker sets can't detect structural variants, rare alleles, or complex polyploid regions. Here's what the transition to long-read sequencing actually looks like and why you don't need to rebuild your program to start.
What Short-Read Sequencing is Costing Your Breeding Program, and What the Data Shows
At matched sequencing depth, short-read low-pass sequencing covered 17% of the peanut genome. Long-read low-pass sequencing covered 55%. A head-to-head study of 127 breeding lines shows what plant breeders are missing with current methods — and what changes when you switch.