Research. Insights. Real talk on genomics.
Science-first content from the researchers building the tools.
Why Can't Short-Read Sequencing Resolve Polyploid Genomes?
Short-read sequencing cannot distinguish between the duplicated chromosomes that define polyploid genomes. Here is what that failure costs — and why long-read low-pass sequencing resolves it.
Long-Read vs. Short-Read Sequencing: Which Should You Use?
Long-read and short-read sequencing are not competing technologies for the same job. Here is how to choose the right method for your research question.
Your Revio Is Ready. Is Your Lab?
HiFi library prep for a PacBio Revio takes a full day of bench time for 8 samples. At scale, it's weeks. Here's what in-house prep is actually costing your lab.
What Short-Read Sequencing is Costing Your Breeding Program, and What the Data Shows
At matched sequencing depth, short-read low-pass sequencing covered 17% of the peanut genome. Long-read low-pass sequencing covered 55%. A head-to-head study of 127 breeding lines shows what plant breeders are missing with current methods — and what changes when you switch.
You Don't Have a Data Problem. You Have a Resolution Problem.
Over the past decade, plant breeding has undergone a data revolution. Sequencing costs have dropped, datasets have grown, and genomic tools are now embedded in modern breeding programs.
And yet—many of the most important traits remain frustratingly difficult to resolve.
Why?