Research, insights, real talk on genomics.
Science-first content from the researchers building the tools.
How do You Build a Better Reference Panel for Genotype Imputation?
A reference panel sets the ceiling on imputation accuracy. Walid Korani, PhD, explains why panels built from arrays and short reads underperform, how long reads change panel construction, and a practical framework for building one that holds up in diverse populations.
Low-Pass Long-Read vs. Low-Pass Short-Read Sequencing: What Changes at the Same Depth?
Two low-pass studies at the same depth can return very different data. A peanut breeding population shows why read length decides what that depth delivers.
What is a Structural Variant and Why Does it Matter in Genomics Research?
SNPs get most of the attention in genomics. Structural variants do most of the work. This post explains what SVs are, why they are systematically underdetected, and what detecting them actually changes.
How Much Coverage Do You Need for Long-Read Low-Pass Sequencing?
The answer to 'how much coverage do I need' depends on your species, your study question, and which variant classes matter to you. This guide breaks it down so you can design a study that works.
Why Can't Short-Read Sequencing Resolve Polyploid Genomes?
Short-read sequencing cannot distinguish between the duplicated chromosomes that define polyploid genomes. Here is what that failure costs — and why long-read low-pass sequencing resolves it.
What Is Long-Read Low-Pass Sequencing?
For years, researchers had to choose between sequencing quality and study scale. LRLP ends that compromise. Here is what it is and how it works.