Research. Insights. Real talk on genomics.
Science-first content from the researchers building the tools.
How Long-Read Low-Pass Sequencing Works in a Pangenome Study
A single reference genome captures one individual's biology — everything else in the population reads as deviation. Here's how long-read low-pass sequencing paired with pangenome graphs recovers the variation standard sequencing misses, and when you actually need it.
What is a Structural Variant and Why Does it Matter in Genomics Research?
SNPs get most of the attention in genomics. Structural variants do most of the work. This post explains what SVs are, why they are systematically underdetected, and what detecting them actually changes.
The Real Cost of Sequencing: What Per-Sample Price Doesn't Tell You
Per-sample price is how sequencing gets sold but it's not how discoveries get made. This post reframes the economics of genomics research from the ground up.
How to Sequence Sex Chromosomes Accurately
Sex chromosomes are among the most difficult regions of any genome to sequence accurately. Hemizygosity, repetitive elements, palindromic regions, and structural variants make short-read methods unreliable across most of the chromosome length. Long-read low-pass sequencing resolves each of these failure modes — delivering comprehensive variant data across the full sex chromosome at population scale.
Why Can't Short-Read Sequencing Resolve Polyploid Genomes?
Short-read sequencing cannot distinguish between the duplicated chromosomes that define polyploid genomes. Here is what that failure costs — and why long-read low-pass sequencing resolves it.
Long-Read vs. Short-Read Sequencing: Which Should You Use?
Long-read and short-read sequencing are not competing technologies for the same job. Here is how to choose the right method for your research question.