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How to Sequence Sex Chromosomes Accurately
Sex chromosomes are among the most difficult regions of any genome to sequence accurately. Hemizygosity, repetitive elements, palindromic regions, and structural variants make short-read methods unreliable across most of the chromosome length. Long-read low-pass sequencing resolves each of these failure modes — delivering comprehensive variant data across the full sex chromosome at population scale.
What Is Long-Read Low-Pass Sequencing?
For years, researchers had to choose between sequencing quality and study scale. LRLP ends that compromise. Here is what it is and how it works.
How to Transition from SNP Arrays to Sequencing in Your Breeding Program
SNP arrays have served plant breeding well. But fixed marker sets can't detect structural variants, rare alleles, or complex polyploid regions. Here's what the transition to long-read sequencing actually looks like and why you don't need to rebuild your program to start.