Research, insights, real talk on genomics.
Science-first content from the researchers building the tools.
How do You Build a Better Reference Panel for Genotype Imputation?
A reference panel sets the ceiling on imputation accuracy. Walid Korani, PhD, explains why panels built from arrays and short reads underperform, how long reads change panel construction, and a practical framework for building one that holds up in diverse populations.
Low-Pass Long-Read vs. Low-Pass Short-Read Sequencing: What Changes at the Same Depth?
Two low-pass studies at the same depth can return very different data. A peanut breeding population shows why read length decides what that depth delivers.
Is Genotyping-by-Sequencing Still Worth It? What Plant Breeders Need to Know
GBS was a breakthrough when it launched. The question now is whether the tradeoffs it requires are still acceptable given how much sequencing technology has changed. This post gives you a framework to evaluate that honestly.
How Long-Read Low-Pass Sequencing Works in a Pangenome Study
A single reference genome captures one individual's biology — everything else in the population reads as deviation. Here's how long-read low-pass sequencing paired with pangenome graphs recovers the variation standard sequencing misses, and when you actually need it.
What is a Structural Variant and Why Does it Matter in Genomics Research?
SNPs get most of the attention in genomics. Structural variants do most of the work. This post explains what SVs are, why they are systematically underdetected, and what detecting them actually changes.
How Much Coverage Do You Need for Long-Read Low-Pass Sequencing?
The answer to 'how much coverage do I need' depends on your species, your study question, and which variant classes matter to you. This guide breaks it down so you can design a study that works.
How to Sequence Sex Chromosomes Accurately
Sex chromosomes are among the most difficult regions of any genome to sequence accurately. Hemizygosity, repetitive elements, palindromic regions, and structural variants make short-read methods unreliable across most of the chromosome length. Long-read low-pass sequencing resolves each of these failure modes — delivering comprehensive variant data across the full sex chromosome at population scale.
What Is Long-Read Low-Pass Sequencing?
For years, researchers had to choose between sequencing quality and study scale. LRLP ends that compromise. Here is what it is and how it works.
How to Transition from SNP Arrays to Sequencing in Your Breeding Program
SNP arrays have served plant breeding well. But fixed marker sets can't detect structural variants, rare alleles, or complex polyploid regions. Here's what the transition to long-read sequencing actually looks like and why you don't need to rebuild your program to start.