Research, insights, real talk on genomics.
Science-first content from the researchers building the tools.
How do You Build a Better Reference Panel for Genotype Imputation?
A reference panel sets the ceiling on imputation accuracy. Walid Korani, PhD, explains why panels built from arrays and short reads underperform, how long reads change panel construction, and a practical framework for building one that holds up in diverse populations.
Low-Pass Long-Read vs. Low-Pass Short-Read Sequencing: What Changes at the Same Depth?
Two low-pass studies at the same depth can return very different data. A peanut breeding population shows why read length decides what that depth delivers.
Is Genotyping-by-Sequencing Still Worth It? What Plant Breeders Need to Know
GBS was a breakthrough when it launched. The question now is whether the tradeoffs it requires are still acceptable given how much sequencing technology has changed. This post gives you a framework to evaluate that honestly.